Volume 19 • Number 1 January 2014
EDITORIAL
The Thorough QT Study: Is Its Demise on the Horizon?
Philip T. Sager and Peter Kowey
REVIEW ARTICLES
ECG Diagnosis and Classification of Acute Coronary Syndromes
Yochai Birnbaum, James Michael Wilson, Miquel Fiol, Antonio Bayes de Luna, Markku Eskola,
and Kjell Nikus
Early Repolarization Syndrome: Electrocardiographic Signs and Clinical
Implications
Ciprian Rezus, Mariana Floria, Victor Dan Moga, Oana Sirbu, Nicoleta Dima, Simona Daniela Ionescu,
and Valentin Ambarus
ORIGINAL ARTICLES
Heart Rate Variability and Procedural Outcome in Catheter Ablation for
Atrial Fibrillation
Geoffrey E.J. Seaborn, Keith Todd, Kevin A. Michael, Adrian Baranchuk, Hoshiar Abdollah,
Christopher S. Simpson, Selim G. Akl, and Damian P. Redfearn
Electrocardiographic Reference Values for a Population of Older Adults
in Sub-Saharan Africa
Matthew J. Dewhurst, Luigi Y. Di Marco, Felicity Dewhurst, Philip C. Adams, Alan Murray,
Golda P. Orega, Julius C. Mwita, Richard W. Walker, and Philip Langley
Fragmented Surface ECG Was a Poor Predictor of Appropriate Therapies in Patients
with Chagas’ Cardiomyopathy and ICD Implantation (Fragmented ECG in CHAgas’
Cardiomyopathy Study)
Adrian Baranchuk, Francisco Femenia, Juan Cruz Lopez-Diez, Claudio Muratore, Mariana Valentino,
Enrique Retyk, Nestor Galizio, Darıo Di Toro, Karina Alonso, Wilma M. Hopman, and Rodrigo Miranda
on behalf of the FECHA Study Investigators
Celecoxib-Induced Change in Atrial Electrophysiologic Substrate in Arthritis
Patients
Katerina Pizzuto, Henry L Averns, Adrian Baranchuk, Hoshiar Abdollah, Kevin A. Michael,
Christopher Simpson, and Damian P. Redfearn
P-Wave Abnormality Predicts Recurrence of Atrial Fibrillation after Electrical
Cardioversion: A Prospective Study
Hanney Gonna, Mark Michael Gallagher, Xiao Hua Guo, Yee Guan Yap, Katerina Hnatkova,
and A. John Camm
HEREDITARY ARRHYTHMIA CORNER
Single Nucleotide Polymorphisms in Proximity to K-Channel Genes Are Associated
with Decreased Longitudinal QTc Variance
Yuliya Mints, Vadim Zipunnikov, Irfan Khurram, Hugh Calkins, and Saman Nazarian
CARDIAC SAFETY
The IQ-CSRC Prospective Clinical Phase 1 Study: “Can Early QT Assessment Using
Exposure Response Analysis Replace the Thorough QT Study?”
Borje Darpo, Nenad Sarapa, Christine Garnett, Charles Benson, Corina Dota, Georg Ferber,
Venkateswar Jarugula, Lars Johannesen, James Keirns, Kevin Krudys, Catherine Ortemann-Renon,
Steve Riley, Danise Rogers-Subramaniam, and Norman Stockbridge
Use of Continuous ECG for Improvements in Assessing the Standing Response
as a Positive Control for QT Prolongation
Anthony A. Fossa, Meijian Zhou, Nuala Brennan, Patrick Round, and John Ford
CASE REPORTS
Bidirectional Ventricular Tachycardia?
Jos´e L. Serra, Julian A. Caresani, and Julio O. Bono
Very Early Recurrence of Takotsubo Syndrome
Zhaolong Xu, Qiang Li, Renguang Liu, and Yuhong Li
Vagal Enhancement Linking Abnormal Blood Pressure Response and Subendocardial
Ischemia in Hypertrophic Cardiomyopathy
Tatsuya Kawasaki and Hiroki Sugihara
LETTER TO THE EDITOR
T-Wave Alternans, ST-Segment Depression, Left Ventricular Hypertrophy, and
Mortality Risk in Patients with Ischemic Cardiomyopathy: Some Possible
Confounding Factors
John E. Madias
Volume 19 • Number 2 March 2014
REVIEW ARTICLE
Noninvasive Imaging of Cardiac Excitation: Current Status and Future Perspective
A.W. Maurits van der Graaf, Pranav Bhagirath, Hemanth Ramanna, Vincent J.H.M. van Driel,
Jacques de Hooge, Natasja M.S. de Groot, and Marco J.W. Gotte
ORIGINAL ARTICLES
Number of P-Wave Fragmentations on P-SAECG Correlates with Infiltrated Atrial
Fat
Sindhoora Murthy, Patricia Rizzi, Nathan Mewton, David G. Strauss, Chia Y. Liu,
Gustavo Jardim Volpe, Francis E. Marchlinski, Peter Spooner, Ronald D. Berger, Peter Kellman,
Joao A.C. Lima, and Larisa G. Tereshchenko
Automated Assessment of Cardiac Autonomic Function by Means of Deceleration
Capacity from Noisy, Nonstationary ECG Signals: Validation Study
Christian Eick, Konstantinos D. Rizas, Christine S. Zuern, and Axel Bauer
Diagnostic Accuracy of a New Cardiac Electrical Biomarker for Detection of
Electrocardiogram Changes Suggestive of Acute Myocardial Ischemic Injury
David M. Schreck and Robert D. Fishberg
An Analysis of the U-Wave and Its Relation to the T-Wave in Body Surface Potential
Maps for Healthy Subjects and MI Patients
Małgorzata Fereniec, Gunter Stix, Michał Kania, Tomasz Mroczka, and Roman Maniewski
Heart Rate Variability and Heart Rate Turbulence in Patients with Hematologic
Malignancies Subjected to High-Dose Chemotherapy in the Course of
Hematopoietic Stem Cell Transplantation
Małgorzata Poreba, Rafał Poreba, Paweł Ga´c, Lidia Usnarska-Zubkiewicz, Witold Pilecki,
Ewa Piotrowicz, Ryszard Piotrowicz, Leszek Rusiecki, Kazimierz Kuliczkowski, Grzegorz Mazur,
and Małgorzata Sobieszczanska
Relation of Low Vitamin D to Nonvalvular Persistent Atrial Fibrillation in Chinese
Patients
Wei Ren Chen, Zhi Ying Liu, Yang Shi, Da Wei Yin, Hao Wang, Yuan Sha, and Yun Dai Chen
Holter Electrocardiography Findings and P-Wave Dispersion in Pediatric Patients
with Transcatheter Closure of Atrial Septal Defects
Isa Ozyilmaz, Sinem Ozyilmaz, Hasan Tahsin Tola, Murat Saygi, Neslihan Kiplapinar,
Cansaran Tanıdır, Yakup Ergul, Alper Guzeltas, and Ender Odemis
CARDIAC SAFETY
Comparison of Two Methods of Estimating Reader Variability in QT Interval
Measurements in Thorough QT/QTc Studies
Vaibhav Salvi, Dilip R. Karnad, Vaibhav Kerkar, Gopi Krishna Panicker, Mili Natekar,
and Snehal Kothari
CASE REPORTS
QT Prolongation and T-Wave Alternans during Catheter Ablation of Atrial
Fibrillation: A Case Report
Aditya Saini, Hemal Shah, and Samir Saba
Sustained Ventricular Tachycardia in a Patient with Thalassemia Major
Nermin Bayar, Sakir Arslan, Zehra Erkal, and Selcuk Kucukseymen
EKG Pattern of Brugada Syndrome and Sudden Infant Death Syndrome—Is It Time
to Review the Diagnostic Criteria? Case Report and Review of Literature
Emiliana Franco, Andre Dias, Daniele Teresa, and Kathy Hebert
LETTER TO THE EDITOR
Is Prolonged QTc Sufficient to Predict Survival in Patients with Intracerebral
Hemorrhage?
Yavuzer Koza
Response to Koza
Is Prolonged QTc Sufficient to Predict Survival in Patients with Intracerebral
Hemorrhage?
Clara Hjalmarsson and Lennart Bergfeldt
Volume 19 • Number 3 May 2014
REVIEW ARTICLE
Interaction between Heart Rate and Heart Rate Variability
Jerzy Sacha
ORIGINAL ARTICLES
A Novel Method for Real-Time Atrial Fibrillation Detection in Electrocardiograms
Using Multiple Parameters
Xiaochuan Du, Nini Rao, Mengyao Qian, Dingyu Liu, Jie Li, Wei Feng, Lixue Yin,
and Xu Chen
Impact of Continuous Positive Airway Pressure Therapy on Atrial
Electromechanical Delay and P-Wave Dispersion in Patients with Obstructive
Sleep Apnea
Pınar Turker Bayır, Burcu Demirkan, Omer Bayır, Serkan Duyuler, Hikmet Fırat, Umit Guray,
Yesim Guray, and Emel Cadallı Tatar
Electrocardiographic Findings in Accessory Right Precordial Leads in Adults and
Seniors with Notched S Waves in Lead V1—A Preliminary Study
Zhan Zhong-qun, Kjell C. Nikus, Andres Ricardo Perez-Riera, and Wang Chong-quan
Brief Assessment of Supine Heart Rate Variability in Normal Weight, Overweight,
and Obese Females
Zienab Alrefaie
Sudden Cardiac Arrest in Hemodialysis Patients with Wearable Cardioverter
Defibrillator
Chingping Wan, Charles A. Herzog, Wojciech Zareba, and Steven J. Szymkiewicz
Electrocardiography at Diagnosis and Close to the Time of Death in Pulmonary
Arterial Hypertension
Adriano R. Tonelli, Manfred Baumgartner, Laith Alkukhun, Omar A. Minai,
and Raed A. Dweik
Usefulness of P-Wave Signal Averaging to Predict Atrial Fibrillation Recurrences
after Electrical Cardioversion
Coralie Blanche, Nam Tran, David Carballo, Fabio Rigamonti, Haran Burri,
and Marc Zimmermann
Nonreassuring Fetal Heart Rate Decreases Heart Rate Variability in Newborn
Infants
Tzong-Chyi Sheen, Ming-Huei Lu, Mei-Yu Lee, and Su-Ru Chen
CASE REPORTS
The Use of Fontaine Leads in the Diagnosis of Arrhythmogenic Right Ventricular
Dysplasia
Byron Gottschalk, Michael Gysel, Raimundo Barbosa-Barros, Ricardo Paulo De Sousa Rocha,
Andres Ricardo Perez-Riera, Li Zhang, Guy Fontaine, and Adrian Baranchuk
Reversible T-Wave Inversions and Neurogenic Myocardial Stunning in a Patient with
Recurrent Stress-Induced Cardiomyopathy
Yasushi Akutsu, Kyouichi Kaneko, Yusuke Kodama, Hui-Ling Li, Jumpei Suyama, Tsutomu Toshida,
Hiroyuki Kayano, Akira Shinozuka, Takehiko Gokan, and Youichi Kobayashi
Wide Complex Tachycardia in the Presence of Class I Antiarrhythmic Agents:
A Diagnostic Challenge
Bhaskar Bhardwaj, Ralph Lazzara, and Stavros Stavrakis
Sudden Death Due to Nonarrhythmic Cause in a Patient with L-TGA
Robert M. Hayward, Philip C. Ursell, Elyse Foster, and Zian H. Tseng
Volume 19 • Number 4 July 2014
REVIEW ARTICLES
Vernakalant for the Conversion of Atrial Fibrillation: The New Kid On the Block?
Diego Conde and Adrian Baranchuk
Beneficial Effects of Physical Activity on Baroreflex Control in the Elderly
Maria Teresa La Rovere and Gian Domenico Pinna
Utility of the Exercise Electrocardiogram Testing in Sudden Cardiac Death Risk
Stratification
Marwan M. Refaat, Mostafa Hotait, and Zian H. Tseng
ORIGINAL ARTICLES
Reliability and Validity of Clinician ECG Interpretation for Athletes
Charles Magee, Joshua Kazman, Mark Haigney, Ralph Oriscello, Kent J. DeZee, Patricia Deuster,
Patrick Depenbrock, and Francis G. O’Connor
A Novel ECG-Index for Prediction of Ventricular Arrhythmias in Patients after
Myocardial Infarction
Mathias Hetland, Kristina H. Haugaa, Sebastian I. Sarvari, Gunnar Erikssen, Erik Kongsgaard,
and Thor Edvardsen
Significance and Usefulness of Narrow Fragmented QRS Complex on 12-Lead
Electrocardiogram in Acute ST-Segment Elevation Myocardial Infarction for
Prediction of Early Mortality and Morbidity
Berna Stavileci, Murat Cimci, Baris Ikitimur, Hasan Ali Barman, Sevgi Ozcan, Esra Ataoglu,
and Rasim Enar
Ranolazine for the Suppression of Ventricular Arrhythmia: A Case Series
Eric Yeung, Mori J. Krantz, Joseph L. Schuller, Rita A. Dale, and Mark C. Haigney
Fragmented QRS Predicts the Arrhythmic Events in Patients with Heart Failure
Undergoing ICD Implantation for Primary Prophylaxis: More Fragments More
Appropriate ICD Shocks
Fırat Ozcan, Osman Turak, Ugur Canpolat, Sedat Avci, Derya Tok, Ahmet Isleyen,
Muhammed Cebeci, Huseyin Yuzgecer, Ozgu¨ l Malcok Gurel, Serkan Topaloglu, Dursun Aras,
Fatma Nurcan Basar, and Sinan Aydogdu
QT Restitution Properties during Exercise in Male Patients with Coronary Artery
Disease
Dongdong Zhao, Yidong Wei, Kai Tang, Xuejing Yu, Jing Wen, Jingying Zhang, and Yawei Xu
P-Wave Morphology Is Unaffected by Atrial Size: A Study in Healthy Athletes
Richard Petersson, Hilde M. Berge, Gard F. Gjerdalen, Jonas Carlson, Fredrik Holmqvist,
Kjetil Steine, and Pyotr G. Platonov
Assessment of Inhomogeneities of Repolarization in Patients with Systemic Lupus
Erythematosus
Ahmet Avci, Kenan Demir, Bulent Behlul Altunkeser, Sema Yilmaz, Ahmet Yilmaz,
Ahmet Ersecgin, and Tarik Demir
GENETIC CORNER
Effect of Flecainide on T-Wave Alternans in Andersen–Tawil Syndrome
Hideki Hayashi, Tamiro Kawaguchi, and Minoru Horie
CASE REPORTS
Brugada Phenocopy Clinical Reproducibility Demonstrated by Recurrent
Hypokalemia
Natalia R. Genaro, Daniel D. Anselm, Nahuel Cervino, Ariel O. Estevez, Carlos Perona,
Alejandro M. Villamil, Ruben Kervorkian, and Adrian Baranchuk
Sinus Arrest and Asystole Caused by a Peripherally Inserted Central Catheter
Allison Nazinitsky, Melody Covington, and Laszlo Littmann
Unusual Cause of Syncope in a Patient with Ischemic Heart Disease
Mohit D. Gupta, Girish, Mayank Goyal, MSK Subhendu, and Sanjay Tyagi
Correlation Between ST-Segment Elevation and Negative T Waves in the Precordial
Leads in Acute Pulmonary Embolism: Insights into Serial Electrocardiogram
Changes
Zhan Zhong-qun, Yang Bo, Kjell C. Nikus, Andres Ricardo Perez-Riera, Wang Chong-quan,
and Wang Xian-ming
LETTERS TO THE EDITOR
P-Wave Duration or P-Wave Morphology? Interatrial Block: Seeking for the Holy
Grail to Predict AF Recurrence
Adrian Baranchuk, Diego Conde, Andres Enriquez, and Antoni Bayes de Luna
Response to Baranchuk et al.
Hanney Gonna and Mark M Gallagher
Volume 19 • Number 5 September 2014
INTRODUCTION
Consensus Documents on Current Topics in ECG Interpretation
Wojciech Zareba, Ryszard Piotrowicz, Miguel Fiol, and Antoni Bayes de Luna
REVIEW ARTICLES
The Role of the ECG in Diagnosis, Risk Estimation, and Catheterization Laboratory
Activation in Patients with Acute Coronary Syndromes: A Consensus Document
Yochai Birnbaum, Kjell Nikus, Paul Kligfield, Miguel Fiol, Jose Antonio Barrabes, Alessandro Sionis,
Olle Pahlm, J. Garcia Niebla, and Antonio Bayes de Luna
Negative T Wave in Ischemic Heart Disease: A Consensus Article
Antonio Bayes de Luna, Wojciech Zareba, Miquel Fiol, Kjell Nikus, Yochai Birnbaum,
Rafael Baranowski, Diego Goldwasser, Paul Kligfield, Ryszard Piotrowicz, Gunter Breithardt,
and Hein Wellens
Prinzmetal Angina: ECG Changes and Clinical Considerations: A Consensus Paper
Antonio Bayes de Luna, Iwona Cygankiewicz, Adrian Baranchuk, Miquel Fiol, Yochai Birnbaum,
Kjell Nikus, Diego Goldwasser, Javier Garcia-Niebla, Samuel Sclarovsky, Hein Wellens,
and Gunter Breithardt
ORIGINAL ARTICLES
Myocardial Tissue Perfusion Predicts the Evolution of Fragmented QRS in Patients
with ST-Segment Elevation Myocardial Infarction Undergoing Primary
Percutaneous Coronary Intervention
Firat Ozcan, Osman Turak, Ugur Canpolat, Iskender Kadife, Sedat Avci, Ahmet Isleyen,
Muhammed Cebeci, Ozgu¨ l Malcok Gurel, Fatma Nurcan Basar, Derya Tok, Serkan Topaloglu,
Dursun Aras, and Sinan Aydogdu
Comparison of Cardiogoniometry and ECG at Rest versus Myocardial Perfusion
Scintigraphy
Stefan Weber, Ralf Birkemeyer, Dominik Schultes, Walter Grewenig, and Thomas Huebner
Influence of Atrioventricular Optimization on Hemodynamic Parameters and Quality
of Life in Patients with Dual Chamber Pacemaker with Ventricular Lead in Right
Ventricular Outflow Tract
Artur Klimczak, Adam S. Budzikowski, Marcin Rosiak, Marzenna Zielinska, Bozena Urbanek,
Karol Bartczak, Michał Chudzik, and Jerzy K. Wranicz
Parameters of Heart Rate Variability Can Predict Prolonged Asystole before Head-Up
Tilt Table Test
Erdal Gursul, Serdar Bayata, Selcen Yakar Tuluce, Rida Berilgen, Ozgen Safak, Emre Ozdemir,
and Kamil Tuluce
The Natural History of Multifocal Atrial Rhythms in Elderly Outpatients: Insights
from the “Ikaria Study”
George Lazaros, Christina Chrysohoou, Evaggelos Oikonomou, Dimitrios Tsiachris, Savvas Mazaris,
Erifili Venieri, Kostas Zisimos, Marina Zaromytidou, Maria Kariori, Stamatis Kioufis, Christos Pitsavos,
and Christodoulos Stefanadis
Short QT in a Cohort of 1.7 Million Persons: Prevalence, Correlates, and Prognosis
Carlos Iribarren, Alfred D. Round, Jonathan A. Peng, Meng Lu, Arthur L. Klatsky, Jonathan G. Zaroff,
Taylor J. Holve, Amit Prasad, and Paul Stang
CASE REPORTS
A New Type of Dual Atrioventricular Nodal Nonreentrant Tachycardia
Krzysztof Kaczmarek, Jan Ruta, Jerzy Wranicz, and Pawel Ptaszynski
Coexistence of Wolff–Parkinson–White and Brugada Syndrome: Mere Curiosity?
Elisabeth Kaiser, Luciana Sacilotto, Francisco Darrieux, and Eduardo Sosa
LETTER TO THE EDITOR
LMCA Disease and T-Wave Positivity in Lead aVR
Nihal Tefik and Atila Bitigen
Volume 19 • Number 6 November 2014
REVIEW ARTICLES
Correlation of Electrocardiogram and Regional Cardiac Magnetic Resonance Imaging
Findings in ST-Elevation Myocardial Infarction: A Literature Review
Irina Rinta-Kiikka, Suvi Tuohinen, Pertti Ryymin, Petteri Kosonen, Heini Huhtala,
Anton Gorgels, Antonio Bayes de Luna, and Kjell Nikus
Left Ventricular Hypertrophy: The Relationship between the Electrocardiogram and
Cardiovascular Magnetic Resonance Imaging
Ljuba Bacharova and Martin Ugander
QRS-T Angle: A Review
Andrew Oehler, Trevor Feldman, Charles A. Henrikson, and Larisa G. Tereshchenko
ORIGINAL ARTICLES
Electrocardiogram Patterns during Hemodynamic Instability in Patients with Acute
Pulmonary Embolism
Zhong-qun Zhan, Chong-quan Wang, Kjell C. Nikus, Chao-rong He, Jin Wang, Shan Mao,
and Xiong-jian Dong
Relationship of Electrocardiographic Left Ventricular Hypertrophy to the Presence of
Diastolic Dysfunction
Joseph M. Krepp, Fay Lin, James K. Min, Richard B. Devereux, and Peter M. Okin
QT Dispersion in HIV-Infected Patients Receiving Combined Antiretroviral
Therapy
Wanwarang Wongcharoen, Somkhuan Suaklin, Nualnit Tantisirivit, Arintaya Phrommintikul,
and Nipon Chattipakorn
Evolution of Electrocardiographic Abnormalities in Association with Neuromuscular
Disorders and Survival in Left Ventricular Hypertrabeculation/Noncompaction
Claudia Stollberger, Daniel Gerger, Peter Jirak, Christian Wegner, and Josef Finsterer
QT Interval Prolongation in End-Stage Liver Disease Cannot Be Explained by
Nonhepatic Factors
Divyang Patel, Prabhpreet Singh, William Katz, Christopher Hughes, Kapil Chopra,
and Jan Nemec
CARDIAC SAFETY
Use of ECG Restitution (Beat-to-Beat QT-TQ Interval Analysis) to Assess
Arrhythmogenic Risk of QTc Prolongation with Guanfacine
Anthony A. Fossa, Meijian Zhou, Antoine Robinson, Jaideep Purkayastha, and Patrick Martin
CASE REPORTS
Asystole Detected by Implantable Loop Recorders: True or False?
Hussam Ali, Antonio Sorgente, Elisabetta Daleffe, and Riccardo Cappato
Piezoelectric Electrocardiographic Artifact in a Patient after Surgery with
Bradycardia and Hypotension
Richard Cheng and Tarun Chakravarty
U Wave Variability in the Surface ECG
Piotr Kukla, Adrian Baranchuk, Marek Jastrzebski, and Leszek Bryniarski
LETTERS TO THE EDITOR
Brugada Phenocopy: Morphological Classification and Importance of Provocative
Testing
Byron Gottschalk, Daniel D. Anselm, and Adrian Baranchuk
Response to: Brugada Phenocopy: Morphological Classification and Importance of
Provocative Testing
Mehdi Rambod, Sherif Elhanafi, and Debabrata Mukherjee